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November 29th, 2006 at 08:30pm
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Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O’neal JF, Graham BS, Stokes Peebles R
The role of IL-13 in respiratory syncytial virus (RSV) immunopathogenesis is incompletely described. To assess the effect of IL-13 on primary RSV infection, transgenic mice which either overexpress IL-13 in the lung (IL-13 OE) or non-transgenic littermates (IL-13 NT) were challenged intranasally with RSV. IL-13 OE mice had significantly decreased peak viral titers four days after infection compared to non-transgenic littermates. In addition, IL-13 OE mice had significantly lower RSV-induced weight loss and reduced lung IFN-gamma protein expression compared with IL-13 NT mice. In contrast, primary RSV challenge of IL-13 deficient mice resulted in a small, but statistically significant increase in viral titers on day four after infection, no difference in RSV-induced weight loss compared to wild type mice, and augmented IFN-gamma production on day 6 after infection. In STAT1-deficient (STAT1 KO) mice, where primary RSV challenge produced high levels of IL-13 production in the lungs, treatment with an IL-13 neutralizing protein resulted in greater peak viral titers both four and six days after RSV and greater RSV-induced weight loss compared to mice treated with a control protein. These results suggest that IL-13 modulates illness from RSV-infection Read More
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November 28th, 2006 at 09:30pm
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November 28th, 2006 at 02:00am
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New-U Hoodia is a safe, natural and effective weight loss supplement that helps people lose weight by suppressing food urges and appetite. Certified South Africa New-U Hoodia is for all people motivated to lose weight, feel better and improve their confidence and self esteem. (PRWeb Nov 22, 2006)
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November 27th, 2006 at 05:00am
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Snoring in overweight kids reduced by exercise Netscape.com
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Source: www.netscape.com
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